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Food and Drug Administration (FDA) for the treatment of obesity

Recent Updates: November 24, 2025: Updated Zepbound Self-Pay pricing and added 45-day refill requirement for discounted doses

Zepbound (tirzepatide) is an FDA-approved prescription medication for chronic weight management in adults with obesity or those who are overweight with weight-related health conditions

As dozens of novel agents currently under study seek new indications, the question arises of whether the traditional practice of two confirmatory trials for every indication expansion remains justified, especially when database study emulations that benchmark against previously conducted, closely related reference trials have yielded aligned results 33,34