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These medications work by steady receptor activation, not on-demand use

The success of G12C inhibitors fundamentally changed the perception of KRAS from an "undruggable" target to a clinically actionable oncogenic driver and established the foundation for subsequent KRAS-targeted drug development

During aging, the primary change related to adipose tissue is increased visceral adiposity, and aged adipose tissue shares several pathologies with obese adipose tissue [6]

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