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Altintas also noted that if these findings are confirmed by prospective studies, several important clinical implications emerge. First, clinicians may be less concerned that semaglutide-induced weight loss inherently increases fracture risk in patients with type 2 diabetes

What it does is reduce local inflammation, support the maintenance of remaining tissue, and in some cases improve synovial health in a way that changes the pain experience meaningfully

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In these studies, the applied dose of antidepressants was higher than those used in pain conditions such as FM