Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. PMID: 24717514; PMCID: PMC4107212
Human evidence: Limited anecdotal reports from human users describe significant cognitive enhancement, particularly in memory formation and recall
Injection Frequency : For patients requiring frequent B12 injections, using a thinner gauge needle (especially for SC injections) can reduce tissue trauma and discomfort over time
Gene modulation is another significant mechanism of GHK-Cu