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A substantial body of research links elevated IGF-1 activity and IGF-1R signaling to the proliferation and survival of many tumor types, and epidemiological studies have associated higher circulating IGF-1 with increased risk of certain cancers

Is There Any Clinical Evidence

Similarly, erianin also has potential in the treatment of rheumatoid arthritis, where it inhibits the abnormal activation and polarization of T helper 17 cells by targeting the JAK/STAT3 signaling pathway (89)

Methods: In this study, we established 5-fluorouracil and AZ628-tolerant persister cell models in two colorectal cancer cell lines, namely HCT116 and SW620, and revealed the characteristics of colorectal cancer persister cells by cell viability assay and flow cytometry