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Frataxin-knockout mouse myoblasts, heart, and skin fibroblasts all showed characteristics of ferroptosis, and Nrf2 was downregulated in Friedreichs Ataxia patients and frataxin-knockout mice, while Nrf2 activators EPI-743 or sulforaphane regulated redox imbalances and rescued ferroptosis in frataxin knockout cells
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In effect, the type of cases Dr
Glutathione S -transferase catalyzes the isomerization of ( R )-2-hydroxymenthofuran to mintlactones
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