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Down-regulation of GLP-1 receptor and TCF7L2 mRNA expression both in the intima and media of arteries in obese human subjects Since we obtained the findings suggesting that GLP-1 receptor protein expression in obese subjects is lower compared to that in non-obese subjects, we mechanically separated the excised diseased artery into the intima and media and quantitatively evaluated various gene expression levels in the intima in the obesity and non-obesity group

This may partly explain why the old saying eat breakfast like a king, lunch like a prince and dinner like a pauper is backed by evidence that demonstrates greater weight loss when breakfast is the largest meal of the day and dinner is the smallest

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EXSCEL found a 9% reduction in the relative risk (RR) of three-point MACE