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Sci Adv 9(44):2884 Anand BK, Brobeck JR (1951) Localization of a feeding center in the hypothalamus of the rat

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Researchers started 1,613 adults in the trial on 1 mg of orforglipron and increased the dose every four weeks until patients received 6 mg, 12 mg, and 36 mg, while other patients received a placebo