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To enhance the pharmacological properties of the ruthenium catalyst, provide cancer selectivity for the treatment, and enable the treatment of challenging hypoxic tumors, the metal complexes were covalently conjugated to the side chains of polymers with a carbon fluorinated moiety that could co-deliver oxygen to the tumor

Verghese, J., Abrams, J., Wang, Y

Selectively reducing Gsto2 in iSPNs in vivo prevents dopaminergic dysfunction, rescues energy metabolism and halts the development of motor symptoms in Trkb mutant mice

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