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The main advantage is verification density

77 This modulation can help reduce depression symptoms in patients with MS can be reduced

When you're studying a compound designed to pull three different metabolic levers at once, you absolutely must be certain that the effects you're observing are from the molecule itself and not from contaminants

Under basal homeostatic conditions, Nrf2 is sequestered in the cytoplasm through its interaction with the adaptor protein KEAP1 (Kelch-like ECH-associated protein 1), which targets Nrf2 for ubiquitination and subsequent proteasomal degradation