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Of the lesser-known side effects mentioned in the study, I have occasionally had patients report fatigue, but its not something I see frequently

These drugs mimic a hormone called GLP-1, which the gut naturally secretes in response to food and which binds to the hormones receptors around the bodyincluding in brain areas involved in appetite regulation and in reward pathways that reduce the pleasure response to food

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To optimise absorption, take levothyroxine on an empty stomach, ideally 30 minutes before breakfast or at bedtime, and separate from other medicines