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SARS-CoV-2 can activate mitochondrial ROS production, especially in older individuals having ROS overproduction, enhancing oxidative stress and promoting endothelial dysfunction, cardiovascular disease and lung injury

Gas Res ., 8 (1), 1923

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Additionally, we examined ternary complex formation using HTRF, which showed that RNK06138 could induce HSP90ERK5-CHAMPERK5 ternary complex formation with an IC 50 value of 16.73 nM (Fig