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These two residues are believed to influence the physicochemical properties and the redox potential of the active center and either enhance or impair the hydroxylation of monophenols by changing the ability of water molecules to deprotonate monophenolic substrates 21

NAC supplementation should generally be avoided immediately before or after exercise if you're training for athletic performance, as some research suggests high-dose NAC might interfere with beneficial exercise-induced adaptations

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