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Theory and practice of histological techniques
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a , Dose-response curves showing relative cell number after 72 h of treatment of HCC-1806 cells with vincristine (0-5 nM) in the presence of the MRP1 inhibitor MK-571 (0-15 M) (n = 8 technical replicates from one experiment)
Apart from the modification and inactivation of antioxidant enzymes, simple amplification of ROS in the cytosol robs pheomelanin-containing cells of intracellular antioxidants, such as super oxide dismutase, leaving the cell susceptible to increased DNA damage (1)
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