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Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

Egede LE, Nietert PJ, Zheng D

KPV is a tripeptide (lysine-proline-valine) derived from alpha-melanocyte-stimulating hormone that inhibits NF-B translocation into the cell nucleus, blocking transcription of pro-inflammatory cytokines like TNF-, IL-1, and IL-6

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