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Upon activation by toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE), macrophages initiate the synthesis of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and other inflammatory biomarkers, resulting in further hepatic injury (Guilliams and Scott 2022)

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974-977 Esposito, P., et al., 2003

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