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In experiments with GLP-1R and GCGR blocking monoclonal antibodies, DIO mice were treated 24 h before G49 treatment with GCGRmAb (6 mg/kg, i.p.) and/or with GLP-1RmAb (19.2 mg/kg, i.p.) 70 and further injected G49 every 2 days for 1 week

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The first injection at any new dose tends to produce the strongest side effects

Chapter Headings Introduction Pre-Existing Diabetes (Type 1 and Type 2) in Pregnancy Management GDM Obstetrical Considerations in Women with Gestational Diabetes (See Section Entitled Obstetrical Considerations in Women with Pre-Existing Diabetes and Gestational Diabetes) Other Relevant Guidelines Author Disclosures Key Messages Pre-Existing Diabetes Preconception and During Pregnancy All women with pre-existing type 1 or type 2 diabetes should receive preconception care to optimize glycemic control, assess for complications, review medications and begin folic acid supplementation