In: Paolo V, Laszlo H (eds) Thyroid diseases: pathogenesis, diagnosis, and treatment, 1st edn
In contrast, decreased expression of mitochondrial ferritin can initiate mitochondrial autophagy through the ROS/PINK1/Parkin pathway, leading to the accumulation of ferritin and the enhancement of ferroptosis in osteoblasts ( Figure 3 ) (135)
Liproxstatin-1, a spiroquinoxalinone derivative, suppresses ferroptosis by reducing ROS and activating the Nrf2/HO-1 pathway, restoring memory function, reducing brain atrophy, and alleviating neurological deficits (210)
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