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As will be discussed, MMR has been suggested to sensitize GBM to TMZ [40]

We have reviewed the mechanism of the Trx and glutathione antioxidant systems, and the roles of these two antioxidant systems in melanogenesis, suggesting that antioxidants have the potential to act as depigmenting agents for the treatment of human hyperpigmentation disorders

Traynor BJ, et al

It has the unique ability to selectively act as an agonist or antagonist in a dose- and tissue-specific manner and has been shown to improve skin repair while exerting anti-neoplastic and chemopreventive properties in both in vitro and in rodent models (Emmerson et al., 2010