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doi: 10.1210/jc.2018-00509 37 HeufelderAEWenzelBEBahnRS

Second, reference product manufacturers have used large rebate offers to maintain formulary preference with major PBMs, creating a situation where the lower-priced biosimilar is not always the lower-cost option from a formulary management standpoint

The theoretical concern remains unconfirmed in humans but is biologically plausible given the peptide's pro-vascular activity

We will cover what we know from available data and clinical experience, what we do not know due to limitations in human trials, and what practical steps reduce risk the most