Additional ligands such as RGD peptide, chlorotoxin, and Angiopep-2 further expand targeting options by exploiting receptors or proteins overexpressed in GBM or BBB transporters, thereby improving nanoparticle penetration, uptake, and therapeutic efficacy
Indeed, some early liposome formulations initially suffered stability issues (e.g., payload leakage, short shelf-life), and a few reports showed inconsistent results, highlighting minor contradictions in performance until manufacturing techniques were optimized
Red flags include unwillingness to provide testing documentation, prices dramatically below market rates, and lack of professional customer service
To further note, in the field of weight-loss treatment, significant work is underway in parallel, on GIP agonist, amylin agonist, glucagon agonist, PYY agonist, either separately or in combination especially with GLP-1 agonist