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[168] [169] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [170] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk

Caution should be exercised in patients with a history of kidney disease because Ozempic can worsen renal function in some patients

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Key Takeaways Generic semaglutide will not be available until at least 2031 in the U.S., when Novo Nordisks patents begin expiring