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Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes

Cost-effectiveness of GLP-1 RAs Interpretation of our findings for GLP-1 RAs is complex

Some providers explore strategies like splitting the semaglutide dose twice weekly or splitting the tirzepatide dose to maintain more consistent blood levels throughout the week, which may improve efficacy at the same total weekly dose