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In previous studies, Sphingomonas , Bacillus , and Cyanobacteria were considered to be beneficial to plant growth and to protect plants from pathogens ( Pseudomonas , Pantoea , and Ralstonia are typical phytopathogenic genera associated with tobacco

The oldest sample came from an adult male excavated in Russias Ural Mountain region, dating from the late Iron Age around 1,500 years ago

Among adults, most smoking-related deaths were attributed to lung cancer (124,813), ischemic heart disease (81,976), and chronic airways obstruction (64,735)

Furthermore, participant demographics frequently favor particular groups, such as those who are obese or have diabetes, which may limit generalizability to larger smoking populations