The Nrf2KEAP1 pathway stands as a master regulator of this balance, transcriptionally activating genes involved in GSH biosynthesis (GCLC, GCLM, GSR, and GSS), iron metabolism (FTL, FTH1, FPN1, and HO-1), and redox defense (SLC7A11, GPX4, and NQO1)all of which directly modulate ferroptosis susceptibility (283, 284)
There appear to be two ways that it does so
The pyruvate can then be decarboxylated by the PDHc and the resulting acetyl-CoA can enter the TCA cycle ultimately allowing for glutamine carbons to be oxidized for ATP synthesis
Additionally, L-theanine can help improve focus and mental clarity, making it a good choice for people who want to relax without feeling drowsy