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doi: 10.1002/ijc.25431 54 Ishak GabraMBYangYLiHSenapatiPHanseEALowmanXHet al

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The final results of the STEP1 trial (Semaglutide Treatment Effect in People with obesity) were recently reported in the New England Journal of Medicine

Activation of those receptors enhances: Glucose-dependent insulin secretion Suppresses glucagon release at inappropriate times Slows gastric emptying Reduces appetite signals in the brain The combined GLP-1 and GIP activity produces more substantial metabolic effects than GLP-1 alone in clinical trials, resulting in better glycemic control and a larger average weight loss