PE234000: β-GlcNAc-PEG3-Azide label-new a tumor-associated carbohydrate antigen and

a tumor-associated carbohydrate antigen and ligand for Siglecs and anti-STn antibodies relevant to cancer immunology

73 / / Fedratinib-d8 / Inrebic-d8

Synthetic MUC-1 (di-STn) glycopeptide with C-terminal Cysteine

Fmoc-Ser(β-GlcNAc-(1-3)-α-GalNAc)-OH

PE234000: β-GlcNAc-PEG3-Azide label-new a tumor-associated carbohydrate antigen andC14H26N4O8 378. 38 A D N acetylglucosamine (GlcNAc) ligand equipped with an azide handle through a hydrophilic PEG3 spacer. The terminal azide couples to alkynes via copper catalyzed azide alkyne cycloaddition (CuAAC) or to DBCO and related strained alkynes via copper free click chemistry, forming stable 1,2,3 triazole linkages. This compound provides a N acetylglucosamine (GlcNAc) building block for glycoconjugate synthesis and the construction of