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Laser Therapy: This treatment makes use of high-energy beams to break down melanin in the skin and reduce the hyperpigmentation of the face

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By providing a common framework, the guidance helps shift the conversation from whether NAMs can be considered to how they can be appropriately applied to answer specific regulatory questions, e.g., derisking treatmentrelated findings observed in animal studies with humanrelevant mechanistic data

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Several studies have also indicated that NETs-mediate the activation of the NLRP3 inflammasome in macrophages of lupus patients, subsequently promoting IL-1 production via ROS and K + efflux (85)

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