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Summary Keywords chronic kidney disease-mineral and bone disorder, immune dysregulation, vascular calcification, osteoimmunology, fibroblast growth factor 23 Citation Xu B, Ma R, Wu Y, Liu C and Song X (2025) Immune mechanisms in chronic kidney disease-mineral and bone disorder: current insights and therapeutic implications

Ferroptotic cancer cells also release danger-associated lipids and iron intermediates that recruit and activate macrophages, creating positive or negative regulatory loops ( 5 Iron homeostasis and immune regulation in the tumor microenvironment 5.1 Impact of macrophage polarization states on iron metabolism During early tumorigenesis, M1-type tumor-associated macrophages (TAMs) facilitate cellular iron uptake via transferrin receptor 1 (TfR1/CD71), while ferritin (FT) restricts iron efflux, resulting in iron sequestration