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For patients experiencing significant symptoms, temporarily pausing therapy, maintaining the current dose for an additional 2-4 weeks before advancing, or implementing smaller dose increments when formulation allows, may improve tolerance

Tan ALY, Forbes JM, Cooper ME (2007) AGE, RAGE, and ROS in diabetic nephropathy

Additional information Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work