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Neither route is universally superior

Recent studies based on machine learning identified different families of compounds already known to target SnCs, such as cardiac glycosides 38 or molecules mimicking the combination of dasatinib/quercetin 39 , confirming the real potential of this technique

Analysis of the affinity of each haptoglobin polymer for hemoglobin by two-dimensional affinity electrophoresis

However, the significance of tyrosine phosphorylation, to the activity of the SDH complex, was demonstrated when it was shown that blocking the activity of the mitochondrial tyrosine phosphatase, PTPMT1, results in hyperphosphorylation and activation of the SDH complex