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Laule, C

In this issue of the JCI, Durbin and colleagues demonstrate that integrin-linked kinase (ILK) acts as a tumor suppressor in ERMS and as a proto-oncogene in ARMS, and that the opposing functions of this enzyme are dependent on the JNK1 signaling pathway (see the related article beginning on page 1558)

Throughout the manuscript, we critically evaluate the hierarchy and reliability of the evidence by specifically emphasizing methodological limitations, study design flaws, the presence or absence of placebo controls, and baseline population equality

This significantly improves the absorption of its active ingredients