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However, this relationship may depend on TMAO dose (Zeng et al., 2021)

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Specifically, testosterone (the major androgen) mediates sex-biased immune cell functions in natural killer (NK) cells, CD8 + T cells, and neutrophils via AR-dependent genomic and non-genomic pathways, which involves suppressing interferon regulatory factor 8 , activating forkhead box O1 , and modulating T-Box transcription factor 21 at the transcription factor level

[1] According to the FDA label, treatment starts at 2.5 mg once weekly for 4 weeks, then increases by 2.5 mg increments at 4-week intervals as tolerated