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Glutathione, the most abundant endogenous intracellular antioxidant, plays a central role in antioxidant defenses, and irreversible cell damage supervenes when the cell is unable to maintain intracellular glutathione concentrations [41]

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A later dose-response study explored the relationship between T4 dose and functional recovery after stroke, reinforcing that the effect is dose-dependent rather than all-or-nothing

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