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Differences in the response of drugs in animals and in man, and, in particular, differences in drug metabolism, bioactivation and disposition, stimulated the search for human relevant experimental models that could replace the use of animals for human safety assessment and prediction

Wisconsin State Journal

Urolithins are microbial metabolites derived from ellagitannins and ellagic acid, polyphenols naturally present in foods such as berries, pomegranate, and nuts (25)