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Cisplatin-induced kidney toxicity: Potential roles of major NAD+-dependent enzymes and plant-derived natural products

Ristoff E, Hebert C, Njalsson R, Norgren S, Rooyackers O, Larsson A: Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione

There is some data to suggest that ALA is also an excellent chelating agent and protects us from heavy metals, although this is beyond the scope of this discussion