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In accordance with the pivotal role of mitochondria in steering differentiation processes by balancing OXPHOS and glycolysis, compromised mitochondrial function in ClpP IEC mice, as well as ex vivo inhibition of OXPHOS in organoid cultures, was sufficient to impair EEC development

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As the review concludes, The effect of GLP-1 analogues on the gut microbiota may have a positive impact on the long-term treatment of diabetes. However, further work is needed