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Sub-threshold concentrations of Dihexa and HGF or Nlel -AnglV and HGF were used to stimulate hippocampal neurons in vitro to determine whether the angiotensin IV ligands Dihexa and Nlel-AnglV, and HGF affect the same signaling cascade or act on one receptor (c-Met)

Together, they provide a foundation for sharper thinking and steadier emotional balance

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 30% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Key structural characteristics include: The peptide exhibits remarkable stability compared to many bioactive peptides, remaining active in gastric acid conditions and showing resistance to enzymatic degradation, making it suitable for diverse experimental applications