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Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion

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These drugs also have low uptake (less than 2% in the USA) due to several factors, including patients reluctance to seek treatment, lack of addiction training among healthcare providers and considerable stigma surrounding AUD and addiction. - Lorenzo Leggio, et al, Nature Medicine, December 2023 Based on the percentage of people in the United States with alcohol use disorder (11% or ~29.5 million) and the number of people who have received medication for alcohol use disorder in the past year (624,000) and the number of people taking GLP-1 drugs (7 percent of American adults or 18 million), we roughly estimate that more than 3 times as many people with AUD have been incidentally prescribed a GLP-1 in the past year than have been prescribed a medication that is FDA indicated for alcohol use disorder (~2 million vs 624,000, and these groups may overlap)

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