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For instance, although temozolomide can cross the BBB and is therefore commonly employed in clinics to treat gliomas, the response rate of this treatment is only approximately 40% of patients owing to the expression of O6-methylguanine DNA methyltransferase 18 and even goes down to 20% for those suffering from higher-grade gliomas 19

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Moreover, short-term experiments may not be able to detect the impact of ANG II suppression on aldosterone levels, since aldosterone has slower rates of secretion and degradation than ANG II (66)

Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species