The most common cause in a study evaluating melanonychia of all morphologies was found to be subungual hemorrhage (29.1%), followed by nail matrix nevus (21.8%), trauma (14.5%), lentigo (11.6%), and race (8.0%).[9] While in a study evaluating only longitudinal melanonychia, racial melanonychia was seen in 68.6%, trauma in 8.5%, fungal in 7.1%, and mixed etiology in 4.5% of cases.[10] Benign melanocytic hyperplasia and nail apparatus malignancy contributed to 5.7% cases each
Additionally, an increased serotonin concentration and reorganization of serotonergic innervation in the cerebellum of Lurcher mice have also been reported [106]
The peptide's effects on circadian regulation and sleep may provide particular benefit during perimenopause when these systems become disrupted
Chen P-H, Wu J, Ding C-KC, Lin C-C, Pan S, Bossa N, et al