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In general, our result is that chronic ethanol exposure may cause earlier and severer cognitive behavioral impairments in ethanol-exposed APP/PS1 mice
The Journal of Clinical Endocrinology & Metabolism, 75 (2), 530-535
After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10
Her pain often resists treatment and becomes disabling, yet doctors still havent identified the cause
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