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108 JawharS.TrawickaA.JenneckensC.BayerT
This resistance is partially due to heightened and sustained activity of the transcription factor cAMP response element-binding protein (CREB), which prevents inhibition of the anti-apoptotic protein BCL-2 [22]
[3] However, the precise contribution of each receptor pathway to gastrointestinal tolerability in a triple agonist has not been fully characterised in humans, and this attribution should be regarded as informed by class-effect data rather than confirmed mechanism
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