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Major Xenobiotic Categories Xenobiotics are typically grouped into several categories based on the source
GLP-1 Receptor (GLP-1R) Agonism Stimulates glucose-dependent insulin secretion: Enhances pancreatic beta-cell insulin release, thus lowering blood glucose 1,3,4
This leads to hyperactivity of the HPA axis, increased release of CRH, stimulation of the pituitary gland to release ACTH, and disruption in the normal synthesis, release, and degradation of corticosterone by the adrenal cortex
The study could not find any correlation between changes in GLP-1 levels and changes in body weight, IBS, or gastrointestinal symptoms
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