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The researchers observed similar results in the STEP 5 trial

Unlike vitamin B 12 deficiency, folate deficiency is not associated with neurologic symptoms

2018, doi:10.3389/fnins.2018.00049 According to the authors of one paper: Vagal activity provides a protective function to the intestinal epithelial barrier and a low vagal activity makes intestinal epithelium more permeable thus promoting systemic inflammation and chronic disease