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There is no identified upper limit for B12 as it's a water-soluble nutrient, meaning any excess is removed in urine

Many studies have demonstrated that ele- vated UA level in humans is an independent risk factor for hypertension[5], diabetes[6], cardiovascular disease[7], endo- thelial dysfunction[8], coronary artery calcication[9], vascu- lar damage[10], obesity and metabolic syndrome.[11,12] Some reports reveal that physiological concentrations of uric acid could induce gene expression of macrophage-secreted in- ammatory cytokines, such as monocyte chemoattractant protein-1 (MCP-1), and growth factors, such as platelet-de- rived growth factor.[13-15] Some experimental studies report that UA stimulates the synthesis of proinammatory cyto- kines such as IL-1 beta, IL-6 and TNF-alpha.[16] Recent studies have indicated that UA acts as an endoge- nous danger signal and at the same time triggers NOD-like receptor protein 3-dependent inammation

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