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The TRIUMPH-CVOT readout will not arrive until 2028 or later, but it is the study that ultimately decides whether retatrutide is positioned as a full cardiometabolic compound rather than a weight-loss compound alone

While often considered a cosmetic concern, varicose veins can cause symptoms such as aching, heaviness, swelling, itching, and in severe cases, skin changes or ulceration

DOI: 10.1038/84839

The SURMOUNT-4 trial showed clearly that the medication's effects diminish once it is no longer in the body, and appetite typically returns to pre-treatment levels