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Briefly, tissues were homogenized in 500 L of RNAiso plus, with total RNA separated by mixing with 100 L of chloroform, and isolated by isopropanol precipitation

The following key MeSH terms and keywords were used: (Virtual Reality[MeSH] OR Virtual Reality Training) AND (Neurorehabilitation[MeSH] OR Cognitive Rehabilitation OR Cognitive Training) AND (Mild Cognitive Impairment[MeSH] OR Cognitive Decline OR Subjective Cognitive Decline) AND (Cognition[MeSH] OR Executive Function OR Memory Disorders[MeSH] OR Attention[MeSH] OR Cognitive Dysfunction[MeSH]) AND (Quality of Life[MeSH] OR Activities of Daily Living[MeSH])

It has been hard to understand how it contributes to the development of HD either from post-mortem human brain analysis or from rodent models carrying mHTT, as the latter affects many signalling pathways

Many also have the ability to penetrate tissues