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Patients with pre-existing diagnoses of the respective outcome prior to the BTX-A/GLP-1 receptor agonist index date were excluded from each time-to-event analysis

In these trials, which had similar designs and included populations enriched for subjects at high risk for cardiovascular (CV) events [13, 26], there were fewer major adverse CV events (MACE, defined as death from CV causes, non-fatal myocardial infarction [MI] or non-fatal stroke) with semaglutide vs placebo: the hazard ratios were similar for s.c

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The short answer: alcohol interacts with GLP-1 medications in ways that can amplify side effects and reduce effectiveness