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The condition typically progresses through stages, beginning with simple steatosis (fat accumulation alone), potentially advancing to non-alcoholic steatohepatitis (NASH) where inflammation develops, and in some cases progressing to fibrosis, cirrhosis, or hepatocellular carcinoma
Acsl4 fl/fl mice were obtained from Cyagen Biosciences (Jiangsu), and Fsp1 fl/fl mice and Ksp Cre-ERT2 mice were sourced from GemPharmatech (Jiangsu)
For example, Zhongshan Qing et al
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